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In murine models, acute inflammation peaks by day 5, with monocyte infiltration and upregulation of proinflammatory cytokines

Weight regain after discontinuation is also a well-documented concern, which makes having a post-treatment plan just as important as the treatment itself

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In CME_b, CME interacts with residues around the pocket, and the interaction with the C1 region helps it better occupy the pocket position in MD simulation

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