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Burget, citando el ejemplo de dos pacientes para ilustrar el punto: en uno, tras 8 kg de reduccin de peso, la HbA 1c de 8,2 a 5,8 y en la otra -una mujer de 49 aos con sndrome metablico- la terapia con liraglutida (Saxenda ) en una reduccin del IMC de 33 a 29 en 10 meses y, paralelamente, los valores de presin arterial se normalizaron (no fue necesario ningn tratamiento antihipertensivo ms)
It is highly effective but operates through a single receptor pathway
However, for reasons that are incompletely understood, in preclinical and clinical studies, adding either a GIPR agonist or GIPR antagonist to GLP-1R agonism causes additional weight loss 1
In terms of their structural composition, these agents can be divided into two main categories: modified versions of native GLP-1 that are resistant to DPP-4 and those that mimic Ex-4, activating GLP-1 R in a manner that is comparable to that of native GLP-1
doi:10.3390/medicina59040778
USA 108 , 95729577 (2011)
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