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Since the tocopherol moiety in the surfactant (TPGS) is bound, i.e., not free to engage in hydrogen atom transfer, it is likely that the protective effect of TPGS was manifested by a different mechanism, such as formation of micellar particles that physically entrap and immobilize the reactive species
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ABCA1 knockout mice had an impaired glucose tolerance but normal insulin sensitivity, suggesting that these mice suffered from islet -cell dysfunction
