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The standard NHS protocol for B12 deficiency typically involves hydroxocobalamin 1mg intramuscularly three times a week for two weeks (if there's no neurological involvement) or on alternate days until no further improvement (if neurological symptoms are present)
418 Rechallenge strategies, by contrast, operate under the premise of clonal evolution reversibility, whereby reintroducing previously used agents, often after a drug holiday, can resensitize tumors due to regrowth of drug-sensitive clones
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"Antivitamins B 12 - Some Inaugural Milestones"
Clin Maladies Syst Nerveux 7:4151 Vegas-Surez S, Simn J, Martnez-Chantar ML, Moratalla R (2022) Metabolic Diffusion in Neuropathologies: The Relevance of Brain-Liver Axis
NICE recommends continuing GLP-1 therapy only if HbA1c reduces by at least 11 mmol/mol and weight decreases by at least 3% at six months
