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studies have found accumulated oxidative damage occurs from decreased levels of these enzymes rather than increased ROS production [44, 45]
Immediate clinical attention is needed, and dose adjustment or discontinuation should be discussed urgently
Key safety concerns identified in Phase 2 data include elevated resting heart rate, gastrointestinal side effects, increased hypoglycaemia risk when combined with insulin or sulfonylureas, and class-relevant cautions around pancreatitis and thyroid C-cell tumours
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The rule bans pharmacies from selling tirzepatide (sold as Mounjaro) and dulaglutide (sold as Trulicity) to non-Canadians or non-permanent residents who don't go in person to pick up the medications
For example, impairments in insulin receptor signaling within the hippocampus and prefrontal cortex can disrupt synaptic plasticity and neurotransmitter balance, potentially leading to cognitive deficits and mood disturbances associated with depression [95]
