Specifically, MSC- Igf1r / mice had less trabecular bone as defined by a significant decrease in the percent of bone volume per tissue volume (BV/TV) ( P =0.01) and trabecular thickness (Tb.Th) ( P =0.002) relative to their wt littermates (Figure 4B)
Cytokine release syndrome (CRS) 59 is a life-threatening hyperinflammatory state linked to viral infections, including SARS-CoV-2, and is a frequent adverse effect after chimeric antigen receptor T cell (CAR-T) therapy 59 , where both IL-6 and neutrophil activation are implicated 60,61
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Sener G, Paskaloglu K, Satiroglu H, Alican I, Kamaz A, Sakarcan A
doi: 10.1038/ng.764 61 FrankeAMcGovernDPBarrettJCWangKRadford-SmithGLAhmadTet al
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