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doi:10.21053/ceo.2022.00815

The combination group had the most significant response, but all experienced significant reductions in skin luminosity differences between hyperpigmented and normal skin areas.Similarly, Handog et al found oral combination therapy with vitamins A, C, E, and procyanidin effective for treating Filipino women with melasma

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The combination supports every phase of wound healing: faster resolution of inflammation, better granulation tissue, and improved remodeling