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6g), low plasma clearance (0.26 mL/min/kg), and C max of 89.4 g/mL (48.5 M molar concentration), which was 60-fold excess of 2012 plasma concentration compared to required in vitro therapeutic levels (focal adhesion IC 50 = 0.8 M)

Across diverse pathogens-viruses, bacteria, fungi, and parasites-common themes emerge, including disruption of mitochondrial bioenergetics, induction of oxidative stress, modulation of mitochondrial dynamics, and interference with immune signaling pathways

(PubMed) Nikiforov A, Kulikova V, Ziegler M