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Experimentally, when retinoic acid, the most active metabolite of vitamin A, is administered in noise-exposed mice, it protects the cochlea by reducing significantly the apoptosis of hair cells and consequently, inducing a faster recovery of the auditory thresholds when compared to untreated animals (Ahn et al., 2005, 2013
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The dye cannot pass through viable cell membranes and thus only binds DNA via the compromised membranes of dead cells (Figure 2)
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