By dosage, the mean changes were: 500 mcg: 127% 750 mcg: 176% (single study) 1,000 mcg: 280% 1,500 mcg: 310% 2000 mcg: 260% 5,000 mcg: 62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways
Its 536-patient trial found no significant weight loss vs placebo
This suggests that long-term maintenance on an LD rich in carbohydrates may confound some of the microbiome differences commonly reported between mice on HFDs and those on lean control diets which contain fewer carbohydrates
Ashu Agarwal Ophthalmologist 24 Years MBBS, MS Delhi Apollo Hospitals Indraprastha, Delhi Dr Deepti Govila Ophthalmologist 26 Years MBBS, MS Ophthalmology Delhi Apollo Hospitals Indraprastha, Delhi Dr
Standard Dosing Ranges: The typical dosage range for AOD-9604 varies depending on route of administration
Mechanistically they do not overlap (GLP-1 agonists work through appetite and gastric emptying, this works on adipocyte lipogenesis and NAD+), and the mouse data specifically showed fat loss without reduced food intake, so they are not redundant
