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Before procedures/anesthesia: Current multi-society guidance says most patients can continue GLP-1s, but plans should be individualized with your surgeon/anesthesiologistespecially if you have significant GI symptoms
Then, GS-THT + is metabolized via a -elimination reaction to obtain -glutamyl-dehydroalanyl-glycine (EdAG), which reacts with a second GSH to form lanthionine GSG, a non-reducible analogue of GSH
The drug causes a reddish discoloration of the urine (chromaturia, which can look like blood in the urine), and of the skin
Onofrj et al., 2013
It is a tripeptide, which means it is made of three amino acids: cysteine, glycine, and glutamic acid
1 No dose adjustment is needed in patients who have renal toxicity (acetaminophen can also be toxic to the kidneys)
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