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Vitamin C

Diarrhea affected 13-16% of patients with diabetes and up to 30% in obesity trials, while vomiting occurred in 5-9% of those treated with tirzepatide for diabetes and up to 24% in obesity studies

These protective effects were consistent regardless of whether the patients had diabetes or obesity

Metformin is sometimes used off-label for managing symptoms of polycystic ovary syndrome (PCOS), such as insulin resistance and irregular menstrual cycles

Neither drug causes glycosuria, and neither creates favorable conditions for bacterial growth in the urinary tract

To offset these pressures, Ipsen has successfully launched Iqirvo (elafibranor) for primary biliary cholangitis and Bylvay (odevixibat) for rare liver diseases, and acquired multiple innovative pipeline assets in 2024