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Phase II liver detoxification involves a process called conjugation
These mechanisms are relevant to both aging biology and cancer biology, which is why the topic appears in scientific discussions
JCI Insight (2017) 2:e88553
Evidence from existing animal and cellular models suggests that this variability may be partly attributable to genetic variants affecting the HSF1/HSP-mediated heat shock response pathway, as well as to individual differences in basal and inducible molecular chaperone levels (Rong et al., 2019
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These assays typically involve enzymes like glutathione reductase or glutathione peroxidase, which interact with glutathione and produce a measurable change in absorbance or color
