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Nutrients, 11 (3), 649
They are in full-scale endocrine rebellion
For example, in hereditary leiomyomatosis and renal cell cancer (HLRCC), a high level of fumarate caused by genetic mutation of fumarate hydratase induces the succination of Kelch-like ECH-associated protein 1 (KEAP1) accompanied by the consumption of a fumarate molecule 134,135
18 Exendin-4, a GLP-1 analogue, also elicits protection against neuroinflammation, which is linked to a decrease in stroke risk
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