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In particular, research has highlighted improvements in postprandial glucose control, hepatic glucose output, and peripheral glucose uptakekey endpoints in studies of metabolic disease progression

Although a prior cohort study did not show a statistically significant reduction in major cardiovascular events among patients with no previous history of cardiovascular disease [148], a meta-analysis of eight clinical trials evaluating the effect of GLP-1R agonists on cardiovascular outcomes reported a 14% reduction in major adverse cardiovascular events, with no significant heterogeneity across GLP-1R agonists or subgroups, including patients with or without previous cardiovascular disease [149]

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Keep out from direct light and refrigerate unused pens