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Since hormones are chemical messengers, any imbalance in one hormone can have an impact on the other glands

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Infact in the sleeve gastrectomy the stomach is cut longitudinally, damaging the very distal branches of the gastric vagal nerve, while in the RYGB the stomach is cut transversely, resulting in a damage of the gastric vagal branches very close to their origin from the esophageal plexus (Ballsmider et al., The ANS as a therapeutic target in obesity Based on the physiopatological background above described, it is clear the modulation of ANS may induce weight loss and/or reduce cardiovascular risk in obese patients

Ipamorelin has also been explored as a scaffold for peptidomimetic derivatives in molecular imaging research (e.g., radiolabeled analogues for ghrelin receptor visualization)