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Vitamin B12 is required for the development, myelination, and function of the central nervous system

Acknowledgments This study was supported by the Jiangsu Provincial Medical Youth Talent (grant number QNRC2016653)

The other consistent context in the preclinical literature is a metabolic environment the mouse studies pair the compound with diet/energy-balance conditions rather than testing it in isolation

Statistical differences were determined by an unpaired Students t test or two-way ANOVA with the corresponding two-tailed significance determined

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