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Detailed body composition data from large Phase 3 trials has not been published yet

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Patients were excluded if they met any of the following criteria: (1) receiving concomitant administration of antipsychotics, orexin receptor antagonists (ie, suvorexant and lemborexant), melatonin receptor agonists (ie, ramelteon), sedative antidepressants (ie, trazodone and mianserin), or oral administration of hydroxyzine or haloperidol

Individual susceptibility to negative health effects varies based on genetic differences in detoxification pathways

320, 376 Christ, A

Nevertheless, based on the data brought forward, it seems safe to conclude that the phenomenon of early worsening of pre-existing DRP was secondary to the initial and rapid improvement in glycemic control that occurred in SUSTAIN-6