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126 In a randomized controlled trial, 40 patients with tinnitus (17 of whom also had vitamin B12 deficiency with levels below 250 pg/mL) were treated with weekly intramuscular injections providing 2,500 mcg vitamin B12 or saline (placebo) for six weeks

N Engl J Med 373(22):21172128

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These benefits appear to reflect both improvements in traditional risk factors - weight, blood pressure, lipid profiles, glycemic control - and potentially direct cardioprotective effects mediated by GLP-1 receptors expressed in cardiomyocytes and vascular endothelium

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