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The nasal epithelium provides direct access to the systemic circulation via the submucosal capillary network, bypassing gut breakdown and first-pass hepatic body function two of the principal barriers limiting oral uptake of peptide compounds

Greater weight loss was observed in patients with higher baseline BMI and higher doses

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Conflict of interest Author RMW reports receiving research grants from Boehringer Ingelheim outside the submitted work

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protect from light Documentation: Certificate of Analysis (COA) included Research Applications Pigmentation & Photobiology: Melanogenesis assays, UV-response and photoprotection markers, melanocyte signaling Metabolic/Neuroendocrine: Appetite/energy-balance pathways (MC3R/MC4R), exploratory sexual-function signaling Dermal/Inflammatory: Cutaneous immune modulation and cytokine readouts tied to melanocortin activity Comparative Receptor Pharmacology: MC1R vs