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For haem repletion, 48 h after haem depletion, the medium was replaced with HD medium containing 20 M haemin (HD + haemin) for an additional 24 h
The sympathetic and parasympathetic nervous systems connect the enteric nervous system to the central one and enable two-way signaling between them (Figure 7)
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Nutritional and management interventions are supported by sufficient evidence for near-term implementation, whereas genetic, epigenetic, and microbiome-targeted approaches remain largely at the proof-of-concept stage, requiring rigorous field trials to evaluate their efficacy, safety, and cost-effectiveness under real-world conditions
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