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Obsessive-compulsive disorder (OCD): An RCT in 48 patients found that NAC (2,400 mg/day) as an add-on to fluvoxamine significantly improved Yale-Brown OCD Scale scores compared to placebo over 12 weeks (Afshar et al., J Clin Psychopharmacol, 2012) [72]

Interestingly, DiR to the brain delivered by COXP micelles was further increased when co-administered with GSH [52] - an encouraging synergistic effect by GSH for GSH transporter mediated brain targeting