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In contrast, the powerful beta cell action of exendin-phe1 provides a potential means to avoid tolerability issues associated with high doses of other agents, and might therefore be a novel therapeutic option for T2D
In pre-specified analyses for time to first occurrence of MACE, there were 44 MACE-5 (all-cause death, heart attack, stroke, heart failure event, or coronary revascularization ) events observed in participants randomized to retatrutide (pooled 9 mg and 12 mg) and 52 events observed in those randomized to placebo, resulting in a hazard ratio of 0.82 (95.0% CI: 0.55 to 1.22)
This is why fatigue on semaglutide and GLP-1 fatigue are so common
Another study on collagen production showed that collagen production increased at in the group treated with GHK-Cu, while this rate was determined to be in the group treated with vitamin C cream, and in the group using retinoic acid
A recent randomized study just published in the Lancet in 2025 evaluated 194 folks randomly assigned to Exenatide (n=97) or placebo (n=97)
Effect of selenium status on thyroid disease Selenium deficiency has been associated with a number of adverse thyroid conditions, including hypothyroidism, subclinical hypothyroidism, enlarged thyroid ( Reference Derumeaux, Valeix and Castetbon 74 Reference Rayman, Duntas, Luster, Duntas and Wartofsky 77 ) , thyroid cancer ( Reference Schmutzler, Mentrup and Schomburg 67 , Reference Rayman, Duntas, Luster, Duntas and Wartofsky 77 Reference Lin, Kuo and Chiang 79 ) and AITD, including HT ( Reference Wu, Rayman and Lv 75 , Reference Rayman, Duntas, Luster, Duntas and Wartofsky 77 ) and GD ( Reference Rayman, Duntas, Luster, Duntas and Wartofsky 77 , Reference Bulow Pedersen, Knudsen and Carle 80 )
