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Notably, the GLP-1R agonist liraglutide suppressed exogenous lactate-induced upregulation of the acetyltransferase p300, which has been identified as a writer of histone lactylation by transferring the lactyl group from lactyl-CoA to specific histone lysine residues [16]

Its effectiveness in controlling blood sugar and supporting weight loss has quickly established it as a breakthrough treatment for type 2 diabetes and obesity

And that leads to the side effects potentially of nausea, stomach upset and such

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