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Elevated ROS levels can exacerbate mitochondrial damage, primarily manifested as irreversible ultrastructural pathological changes such as mitochondrial swelling, cristae fragmentation, and membrane rupture [45]
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Furthermore, GLP-1 and glucose-dependent insulinotropic polypeptides have been shown to induce substance P release from sensory nerves expressing TRPV1 and TRPA1, broadening the potential pain modulation mechanisms of GLP-1 and suggesting their application in peripheral pain management 64
(2022) 132(22):e151803
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