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Dihexa reversed learning and memory deficits at concentrations as low as 10^-13 M (picomolar range), approximately 10 million times more potent than BDNF on a molar basis for promoting synaptogenesis
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however, in multiple macrophage research models, it is associated with IL-10 upregulation, suppression of pro-inflammatory signaling, and tolerance-related phenotypes (55, 56)
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An animal intervention study by Everard et al., 2013 presents moderate risk of bias, primarily due to small sample sizes and incomplete reporting of allocation concealment
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