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Cautions and precautions Those with gastrointestinal intolerance, older adults, patients who escalate doses quickly and people taking medications that increase fluid loss such as diuretics may all be more prone to dehydration, Wood said
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Pain at injection site semaglutide is a recognized local adverse reaction affecting approximately 1.2-1.4% of patients using this GLP-1 receptor agonist for type 2 diabetes or weight management
The rebound effect upon GLP-1R agonists withdrawal needs to be investigated further, and new drug developments should aim to mitigate this big limitation and find ways in which GLP-1R agonists could be used as short-term therapies without causing weight regain and cardiometabolic risk reversal
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