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In vivo study Animals and experimental design All animal procedures were approved by the Ethics Committee of the Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Egypt (Approval No.: PSAS-BSU-HAREC.025/08/08), and conducted in accordance with institutional, national, and international animal care guidelines

The change in protonation state occurs at pH 4.07

This is usually accomplished through mechanical crushing techniques

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In this regard, it has been shown that the pharmacological treatment with the classical estrogen receptor antagonist Fulvestrant (ICI-182,780) modifies the proliferative activity of NSPCs without affecting the differentiation toward the oligodendroglial lineage (Okada et al., 2010)

Marci R, Mallozzi M, Di Benedetto L, et al