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The molecular weight sits at 1419 daltons, placing it in the category of small peptides that can readily interact with various biological systems
Bonnefont-Rousselot D, Collin F (2010) Melatonin: action as antioxidant and potential applications in human disease and aging
While regulation of iron metabolism-related proteins or the use of iron chelators can reduce intracellular labile Fe 2+ levels and inhibit ferroptosis, current chelators lack tissue and cellular specificity and may interfere with neurophysiological functions, thereby limiting their clinical applicability
In fact, it has been observed that aberrant NFE2L2 transcript variants missing exon 2, or exons 2 and 3, are present in lung cancers and head and neck cancers
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