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Headache at higher per-injection doses community sources describe dose-splitting or reducing to resolve
All evidence from animal models
Its mechanism of action centers on upregulation of growth factor expression, particularly vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), which accelerate angiogenesis and tissue granulation 5
Tissue strength gradually increases as new collagen matures and integrates with existing structures
Animal studies are interesting, but they are not definitive
Distal Symmetric Polyneuropathy in Diabetes: A Progressive Disorder
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