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Therefore, prioritizing both a balanced diet and a healthy lifestyle can be crucial for optimizing GLP-1 function and supporting metabolic health

NO has also been observed to nitrosylate JNK1 (blocking its autophagy-activating function) (247) and IKK, reducing AMPK phosphorylation while activating mTORC1, leading to autophagy suppression (248, 249)

Christy explains

The degree of weight loss was independently associated with statistically significant improvements in all NASH-related histologic parameters and provides strong evidence that weight loss is an effective treatment for NAFLD

While effective, both GLP-1 agonists and SGLT2 inhibitors should complement lifestyle interventions, including diet, exercise, and weight management

doi:10.3390/medsci13020058