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Biallelic truncating mutations in ZnT5/ZnT6 similarly lead to congenital disorders of glycosylation type II, presenting clinically with hypoglycosylated transferrin, osteopenia, developmental delay and multisystem involvement 78

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The model assumes, for simplicity, that a constant number of nanometer-scale defects are introduced into both the inner and outer membranes of a bacterium

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In the other enzymatic reaction, methylcobalamin supports the methionine synthase reaction, which is essential for normal metabolism of folate