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Additionally, tirzepatide (Mounjaro, Zepbound) represents a dual GIP/GLP-1 receptor agonistnot a GLP-1 receptor agonistavailable for both diabetes management and weight loss, depending on the brand and indication
Some data suggest that those who discontinue regain between 14% and two-thirds of what they lost
The oral version delivers less weight loss than the injection (expected, given lower bioavailability), but still clinically meaningful especially for patients who would never self-inject
observed that CAR T cells undergo metabolic alterations during tumor re-challenge with accumulation of dysfunctional mitochondria and potential impairment in autophagy process, which was also correlated with defect in memory CAR T cell formation
Gatti L, Zunino F
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