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Since cardiovascular complications of diabetes (62, 63) as well as diabetic nephropathy (64) are associated with an imbalance in the activity of RAAS, the interaction with this system could explain some of the beneficial effects of GLP1-RA

After a number of years of robust revenue growth right after the pandemic, states are starting to see slowing revenues, increasing spending demands and a lot of fiscal uncertainty due in part to recent federal actions. In April, the Trump administration scrapped a Biden-era proposal that would have required state Medicaid programs to pay for some GLP-1s for obesity treatment

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The typical taper takes one to two weeks, stepping down through the lower doses before stopping completely

Despite these tracking challenges, the FDA has already documented multiple concerns on compounded GLP-1s, including compounders using semaglutide salts, which are not the same as the active pharmaceutical ingredient

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