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[8] demonstrated that the incretin effect is impaired in patients with T2D

Several studies have proposed a direct biochemical interaction between melatonin and the NRF2 pathway

Natural ways to support glutathione include sleep, exercise, sulfur-rich foods (broccoli, garlic, onions), vitamin C, selenium, and precursors like NAC and glycine

In several experimental studies with animal models of diabetes, treatment with GSK3 inhibitors has shown to enhance insulin signaling and improve insulin resistance [53]

10.1016/j.gene.2017.04.026 289 ZhouC.HuC.WangB.FanS.JinW

Together, these changes may reduce the metabolic strain that can interfere with healthy insulin function and blood sugar regulation