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Akkermansia is one of the few probiotics with real metabolic credibility, and is gaining attention as a gut-driven way to support metabolic markers, and may be especially appealing for people who cant access GLP-1s, dont want to take them, or are looking for something over-the-counter
NNMT plays a role in regulating nicotinamide adenine dinucleotide (NAD+) metabolism, energy expenditure, and cellular signaling pathways
We can discuss b12 injections as part of your weight loss plan or to combat b12 deficiency during a consultation
Clinical trial results showed modest and variable weight loss outcomes
GPs can prescribe B12 injections following appropriate investigation, which should include: Full blood count to identify macrocytic anaemia Serum B12 and folate levels to confirm deficiency (using laboratory-specific reference ranges) Methylmalonic acid and/or homocysteine when B12 results are borderline Intrinsic factor antibodies if pernicious anaemia is suspected Additional tests depending on clinical presentation (e.g., thyroid function, coeliac serology) When both B12 and folate deficiency are present, B12 should be replaced before folate to avoid precipitating subacute combined degeneration of the spinal cord
(JCEM, 2006
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