Endocrine 64 (2), 349366
Recommendations include: 150-300 minutes weekly moderate-intensity aerobic activity Resistance training 2-3 times weekly to maintain muscle mass Non-exercise activity thermogenesis (NEAT) optimization through increased daily movement Pharmacological Alternatives: Beyond GLP-1 receptor agonists, FDA-approved weight loss medications include: Phentermine-topiramate (Qsymia): Appetite suppressant combination Naltrexone-bupropion (Contrave): Affects reward pathways and appetite Orlistat (Xenical, Alli): Lipase inhibitor reducing fat absorption These alternatives have different mechanisms, adverse effect profiles, and efficacy (typically 5-10% weight loss), allowing individualized selection
Not all peptides are appropriate for every individual
(PubMed) McDaniel MA, Maier SF, Einstein GO
Ipamorelin Dosing Schedule (Community-Derived) Phase Assessment Timing Week 1 Daily Dose 100 mcg/day Frequency 1x at bedtime, fasted Phase Titration Timing Weeks 2-3 Daily Dose 200 mcg/day Frequency 1x bedtime, or split 100 mcg AM + 100 mcg PM Phase Standard Timing Weeks 4-8 Daily Dose 200-300 mcg/day Frequency 1-2x daily (AM fasted + bedtime is common) Phase Extended Timing Weeks 9-12 Daily Dose 200-300 mcg/day Frequency Continue if tolerated
What Is GLP-1, and Why It Matters GLP-1 is a medication belonging to the GLP-1 class
