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3 It has been debated for many years whether oral glutathione supplementation translates into increased bioactive levels of glutathione in the body, since many believe that oral glutathione cannot be adequately absorbed and therefore, successfully utilized by the bodys cells
Muhib, M
However, under conditions of oxidative stress and substrate/cofactor (like tetrahydrobiopterin, BH4) depletion during ischemia/reperfusion, eNOS can become uncoupled. In this state, it produces O 2 instead of NO
S., Mendiola, J., Swan, S
Neurology 42:631
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