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GLP-1 agonists have mixed cardiovascular effects

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In an in-vivo study, it has been seen that mitochondrial ROS can have less detrimental effects in worms by increasing their lifespan while increased level of ROS in cytoplasmic may have less lifespan of worms [43]

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Transdermal estrogen (patch or gel) may carry a different clotting and metabolic risk profile than oral estrogen, though the evidence continues to evolve