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One problem with ultra-long-acting injectables is that they are not reversible, and there are certain circumstances in which a patient on a GLP-1 would need to discontinue treatment

Without insurance, brand-name medications can cost $1,000 or more per month

While all these medications mimic GLP-1, they can work in slightly different ways, either by mimicking other hormones or lasting in the body different lengths of time

5 Results based on a January 2026 analysis of 14,203 Noom GLP-1 Rx Program members who actively logged weight over a 40-week period

This raises important questions about how long treatment should continue

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