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6 Given the reduced appetite and potential for muscle loss, protein needs are generally higher for individuals on GLP-1 therapy compared to standard recommendations
Weight loss from GLP-1 therapy reduces the metabolic burden on kidneys, while improved glucose control decreases glycemic stress on renal tissue, and lower blood pressure reduces glomerular hyperfiltration
11 Our research team found that after oral gavage of AHSYB in normal rats, the pharmacokinetic characteristics indicated rapid elimination of AHSYB and low oral bioavailability (approximately 0.3%)
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These attempts led to the synthesis of glucagon-like peptide-1 (GLP-1) analogues