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Zanidatamab (formerly ZW25) was constructed using the IgG1-like heterodimeric Azymetric Fc platform, with an anti-HER2-ECD4 single chain variable fragment (scFv) linked to heavy chain 1 and an anti-HER2-ECD2 fragment antigen-binding (Fab) domain on heavy chain 2

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Sterility loss Signs of contamination : Cloudiness developing Smell changes Visible particles Color changes Prevention : Always use sterile technique, alcohol swabs, clean needles

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