In addition, the insulinotropic effect of the dual GIP/GLP-1 receptor agonist was abrogated by GIP receptor antagonist (GIPRA) in GLP-1R null mice (63)
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It is associated with a reduction in visceral adipose tissue and liver fat, along with a slight proportional increase in subcutaneous fatty tissue in patients with obesity and diabetes, suggesting a degree of compartmental selectivity
Cell Metabolism , 30(1), 6777
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