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Daniel Drucker [Biomarker April 2023] Early Days of Weight Loss Therapies Early Days of Weight Loss Therapies In the late 1800s, thyroid extract was used to speed up metabolism and induce weight loss
A quick mechanism independent of the cell energetical state and a slower one, metabolism dependent, mediate the release of this incretin (53, 72)
This effect is not unique to GLP-1 medications but applies to any significant weight loss intervention
This study had several limitations to consider, including a small sample size and a relatively short follow-up period, both potentially influencing the studys ability to derive substantial statistical findings
Most patients develop tolerance to gastrointestinal symptoms within 4-8 weeks of consistent use
No data support the efficacy of currently marketed patches
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