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The second term is the activation of CBS by SAM and SAH that was discovered by Finkelstein and Martin [22]

Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

Important context: "GLP-3" is not a formal scientific or pharmacological designation

Research-grade oral capsules from reputable suppliers range from $0.80 to $1.50 per 500 mcg dose, translating to $24-45 monthly for standard 500 mcg daily protocols

Furthermore, biocompatibility was assessed through hemolysis, cytotoxicity assays, and in vivo safety studies, confirming its suitability as a safe therapeutic agent

BME, WM, MSM, PC, BO, RL and CG: Participated in the recovery of blood samples and carried out the biochemistry determinations