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Ozempic is better for weight loss (15% vs 3 to 4% body weight) and A1C reduction

Orforglipron doesn't do this

Because it is not known whether Semaglutide passes into breast milk, healthcare providers may advise against breastfeeding while taking the medication

However, elevated GSH levels have been reported in multiple malignanciesincluding those of the bone marrow, breast, colon, larynx, and lungand are associated with tumor progression and increased metastatic potential (50)

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Whether GLP1-RAs therapy alone is sufficient to reverse the suppression of gonadotrophins found in functional hypogonadism in men with obesity and/or T2DM still needs to be clarified