The impact of defective GLP1R cell surface expression suggests that pharmacological chaperons, molecules known to facilitate proper export of proteins to the cell surface, might be of therapeutic relevance for mutation carriers, as already shown for other important metabolic receptors such as melanocortin MC4 receptor
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Increase dietary fiber gradually (vegetables, whole grains, legumes) Gentle physical activity, such as a 2030 minute walk, stimulates gut motility
Managing them successfully involves practicing mindfulness at mealtimes, choosing lower-glycemic sweet foods like dark chocolate and fresh fruit, and using physical activities or hobbies instead of food to distract the brains reward center
I believe that the contributions that these new findings can make, in some cases, to the comorbidities associated with diabetes and obesity and, in others, as neuroprotectors against neurological diseases or psychiatric disorders, are really important