Lancet 392:15191529 Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, Probstfield J, Riesmeyer JS, Riddle MC, Rydn L, Xavier D, Atisso CM, Dyal L, Hall S, Rao-Melacini P, Wong G, Avezum A, Basile J, Chung N, Conget I, Cushman WC, Franek E, Hancu N, Hanefeld M, Holt S, Jansky P, Keltai M, Lanas F, Leiter LA, Lopez-Jaramillo P, Cardona Munoz EG, Pirags V, Pogosova N, Raubenheimer PJ, Shaw JE, Sheu WH, Temelkova-Kurktschiev T (2019) REWIND Investigators
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For patients with established atherosclerotic cardiovascular disease, injectable agents with proven outcome data may still be preferred
However, for San385, the higher ECD dynamics were driven by increased flexibility of the bypass motif induced by the S19K San385 substitution
And I wish it was as easy as saying You should use this much and calling it a day
On the contrary, studies in animal models of IBD suggest that the use of DPP-IV inhibitors decreases disease activity