Results: A total of 26,221 admissions for 12,288 patients with cirrhosis were included (64% male, mean age 63)
13 While permeation enhancers in oral formulations can elevate permeability across cellular barriers by perturbing the cell membrane, excessive doses might trigger GI side effects, including nausea, diarrhea, and diminished appetite
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature
Prednisone may indeed affect mood and mental state, with psychiatric side effects being relatively common
10.1097/RD9.0000000000000131 Reprod Dev Med
[1] [2] Clinical trials demonstrate substantial weight reduction, with participants losing an average of 15-21% of body weight over 72 weeks in the SURMOUNT-1 trial