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Signs and Symptoms of Ankylosing Spondylitis The most common symptom of ankylosing spondylitis is low back pain that develops so gradually that it may go unnoticed in the early stages

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The authors identified that the dorsal raphe nucleus (DR) has serotonergic neurons that secrete serotonin to hypothalamic nuclei and that GLP-1R activation promotes the activity of DR serotonin neurons

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